Research Summary

Mediterranean Diet and Mortality in Older Adults

Summary ID02-HA-RS-00044

Research Summary

Original Publication

Mediterranean Diet in Older Adults: Cardiovascular Outcomes and Mortality from Observational and Interventional Studies—A Systematic Review and Meta-Analysis

Journal

Nutrients, .

Category
02Healthy Aging
Evidence
Meta-analysis
Summary Type
Core

What Was Studied?

The Mediterranean diet has long been associated with cardiovascular health and longevity.

This systematic review and meta-analysis examined whether greater adherence to a Mediterranean dietary pattern was associated with lower mortality and fewer cardiovascular events specifically in older populations.

The researchers included 28 studies involving 679,259 participants from different countries and continents. Twenty-six were observational studies and two were randomized controlled trials.

Studies were eligible when the mean age of participants was over 60 years.

The main outcomes were all-cause mortality, cardiovascular mortality and cardiovascular events.

The researchers also examined outcomes in populations over 70 years of age.

Greater adherence generally reflected a dietary pattern rich in vegetables, fruits, legumes, whole grains, nuts, olive oil and fish, with lower consumption of foods such as red and processed meats.

Key Findings

1. Higher Mediterranean diet adherence was associated with lower all-cause mortality

People with greater adherence to the Mediterranean diet had a 23% lower risk of death from any cause compared with those with lower adherence.

This was one of the clearest findings of the analysis.

2. Cardiovascular mortality was also lower

Greater adherence was associated with a 27% lower risk of cardiovascular death.

This is particularly relevant to longevity because cardiovascular disease remains a major contributor to mortality and loss of healthy life at older ages.

3. Overall cardiovascular events were less frequent

Higher adherence to the Mediterranean diet was associated with a 25% lower risk of overall cardiovascular events.

When non-fatal cardiovascular events were considered separately, however, the evidence was less certain.

This distinction is important. The findings were stronger and more consistent for mortality and overall cardiovascular outcomes than for non-fatal events considered alone.

4. The association with lower mortality remained evident after age 70

In analyses focusing on populations over 70 years of age, greater Mediterranean diet adherence remained associated with lower all-cause mortality.

Evidence for cardiovascular outcomes in this older subgroup was less conclusive, partly because fewer studies and participants were available.

Why It Matters for Longevity

Longevity is influenced by dietary patterns maintained over many years.

The Mediterranean diet combines several nutritional characteristics associated with long-term health. It emphasizes plant foods, whole grains, legumes and nuts, with olive oil as an important source of unsaturated fat and regular consumption of fish.

The findings of this meta-analysis extend beyond individual cardiovascular risk factors.

Greater adherence was associated with lower all-cause mortality, lower cardiovascular mortality and fewer overall cardiovascular events in older populations.

The results also suggest that nutrition continues to matter later in life. Healthy eating should therefore not be viewed only as an early prevention strategy.

A Mediterranean dietary pattern can remain relevant as part of a long-term approach to cardiovascular health and healthy aging.

Clinical Perspective

The large number of participants is an important strength of this analysis.

However, the findings require careful interpretation.

Twenty-six of the 28 included studies were observational. People who closely follow a Mediterranean diet may also differ in physical activity, smoking, socioeconomic factors and other health behaviors.

These differences cannot be completely removed through statistical adjustment.

Results also varied considerably between studies. Definitions of Mediterranean diet adherence, populations and follow-up periods were not identical.

For these reasons, the findings demonstrate a strong and consistent association, but they do not prove that Mediterranean diet adherence itself caused the reported reductions in mortality.

The results should therefore be considered alongside the wider body of evidence supporting Mediterranean-style eating for cardiovascular and long-term health.

Key Takeaway

Greater adherence to a Mediterranean diet was associated with lower all-cause and cardiovascular mortality in older adults. The findings support the Mediterranean diet as an important dietary pattern for long-term cardiovascular health and healthy aging.

Reviewed and Summarized by

Monika Mikulicz-Pasler, MD, PhD

Monika Mikulicz-Pasler, MD, PhD

Specialist in Cardiology

Specialist in Internal Medicine

KCM Longevity Clinic

Source Publication

Title:
Mediterranean Diet in Older Adults: Cardiovascular Outcomes and Mortality from Observational and Interventional Studies—A Systematic Review and Meta-Analysis
Authors:
Furbatto M, Lelli D, Antonelli Incalzi R, Pedone C
Journal:
Nutrients, November 2024.

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