Longevity Research Summaries
Scientific summaries of selected key publications in longevity medicine, translated into clinically relevant insights. Direct link to the original publication.
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Longevity Research Summary
Prevention & Diagnostics
Can Protecting Your Heart Help You Live Longer?
Original Scientific Title
Cardiovascular Aging and Longevity: JACC State-of-the-Art Review
Original Publication
Journal of the American College of Cardiology (JACC)
- Category
- Prevention & Diagnostics
- Evidence
- State-of-the-Art Review
- Summary Type
- Core
This State-of-the-Art Review, published in the Journal of the American College of Cardiology (JACC), explored the complex biological relationship between cardiovascular aging and longevity.
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Showing 8 of 14
Genetics & Longevity
Epigenetics and Aging: Can We Change How Our Genes Work as We Age?
Original Scientific Title
Epigenetics and Aging
Original Publication
Science Advances
- Category
- Genetics & Longevity
- Evidence
- Clinical review
- Summary Type
- Core
Discover how epigenetic changes influence gene regulation during aging and why DNA methylation, chromatin and histone changes may matter for healthy longevity.
Explore summaryGenetics & Longevity
Genetics of Longevity: How Genes Influence Lifespan
Original Scientific Title
Genetics of Human Longevity: From Variants to Genes to Pathways
Original Publication
Journal of Internal Medicine
- Category
- Genetics & Longevity
- Evidence
- Other
- Summary Type
- Core
Discover what genetic studies of exceptionally long-lived people reveal about human longevity and the biological pathways that may help support a longer, healthier life.
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The Genetics of Aging: What Large-Scale Studies Are Revealing
Original Scientific Title
Genetic Architecture of Human Aging and Longevity: Insights from Genome-Wide Association Studies
Original Publication
BMB Reports
- Category
- Genetics & Longevity
- Evidence
- Clinical review
- Summary Type
- Core
Discover what large-scale genetic studies reveal about human aging, longevity and healthspan-and why thousands of genetic variants may shape how we age.
Explore summaryHealthy Aging
The Hallmarks of Health: What Keeps the Human Body Healthy and Resilient?
Original Scientific Title
Hallmarks of Health
Original Publication
Cell
- Category
- Healthy Aging
- Evidence
- Foundational Review
- Summary Type
- Core
Health is usually defined as the absence of disease.
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Can Medicine Predict How You Will Age Before Disease Develops?
Original Scientific Title
From Geroscience to Precision Geromedicine: Understanding and Managing Aging
Original Publication
Cell
- Category
- Genetics & Longevity
- Evidence
- Other
- Summary Type
- Core
For decades, medicine has primarily focused on diagnosing and treating diseases after they develop. Although this approach has significantly improved survival, it has done less to prevent the biological processes that gradually lead to chronic illness.
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Can Cellular Recycling Help Extend Healthy Life?
Original Scientific Title
Essential Role for Autophagy in Life Span Extension
Original Publication
Journal of Clinical Investigation
- Category
- Healthy Aging
- Evidence
- Narrative Review
- Summary Type
- Advanced
This review examined whether autophagy is a common biological mechanism behind interventions that extend lifespan or healthspan in laboratory organisms.
Explore summaryBiological Age
How Damaged Mitochondria May Drive Chronic Inflammation as We Age
Original Scientific Title
Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets
Original Publication
International Journal of Molecular Sciences
- Category
- Biological Age
- Evidence
- Narrative Review
- Summary Type
- Advanced
This review examined how age-related deterioration in mitochondrial quality control may contribute to inflammaging-the persistent, low-level inflammation that frequently develops later in life.
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What Is the Gap Between Lifespan and Healthspan?
Original Scientific Title
Global Healthspan-Lifespan Gaps Among 183 World Health Organization Member States
Original Publication
JAMA Network Open
- Category
- Healthy Aging
- Evidence
- Retrospective Cross-Sectional Global Health Study
- Summary Type
- Latest
One of the greatest successes of modern medicine is that people are living longer than ever before. However, living longer does not necessarily mean living healthier.
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