Research digest
Research & Discoveries
A physician-curated research digest. Each entry distills a peer-reviewed publication into clinical context: what was studied, what was found, and why it matters for longevity medicine — with full references to the original work.
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Epigenetic Age Acceleration and All-Cause Mortality: A 15-Year Prospective Cohort
GrimAge acceleration predicts mortality independent of chronological age and lifestyle factors.
A landmark cohort study demonstrates that epigenetic age acceleration — measured via the GrimAge clock — independently predicts all-cause and cause-specific mortality over 15 years of follow-up.
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Essential reading
Polygenic Risk Scores for Cardiovascular Disease: Clinical Utility Review
A systematic review evaluates whether polygenic risk scores meaningfully improve cardiovascular risk prediction beyond traditional clinical models.
·7 min
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Cardiorespiratory Fitness and Long-Term Mortality: Updated Meta-Analysis
An updated meta-analysis of 37 cohort studies confirms cardiorespiratory fitness as one of the most powerful modifiable predictors of longevity, surpassing many traditional risk factors.
·5 min
Sleep Duration, Fragmentation, and Cognitive Decline in Midlife Adults
A prospective study of 5,600 midlife adults links U-shaped sleep duration patterns and sleep fragmentation to faster cognitive decline over eight years.
·5 min
Gut Microbiome Diversity and Systemic Inflammation in Older Adults
Cross-sectional analysis of 2,100 adults over 65 links reduced gut microbiome diversity to higher IL-6, CRP, and clinical frailty scores.
·6 min
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